Nimesulide decreases superoxide production by inhibiting phosphodiesterase type IV.

@article{Bevilacqua1994NimesulideDS,
  title={Nimesulide decreases superoxide production by inhibiting phosphodiesterase type IV.},
  author={Maurizio T Bevilacqua and Tarcisio Vago and Gabriella Baldi and Erasmo Renesto and Franco Dallegri and Guido Norbiato},
  journal={European journal of pharmacology},
  year={1994},
  volume={268 3},
  pages={415-23}
}
Nimesulide, the prototype of a new class of anti-inflammatory drugs, dose-dependently decreases the production of the superoxide anion (O2-.) in N-formyl-methionyl-leucyl-phenylalanine (fMLP)- and in phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes. The inhibition of O2-. is possibly related to its inhibitory effect on… CONTINUE READING