Nimesulide aggravates kainic acid-induced seizures in the rat.

  title={Nimesulide aggravates kainic acid-induced seizures in the rat.},
  author={Tina Kunz and Ernst H. Oliw},
  journal={Pharmacology & toxicology},
  volume={88 5},
Treatment of rats with kainic acid (10 mg/kg, intraperitoneally) triggers limbic seizures. Cyclooxygenase-2 mRNA is expressed in the hippocampus and cortex after 8 hr and marked cell loss occurs after 72 hr in the CA1-CA3 areas of the hippocampus. We examined the effect of the cyclooxygenase-2 inhibitor, nimesulide (N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide), on kainate-induced seizures and delayed neurotoxicity. Nimesulide (10 mg/kg, intraperitoneally) was well tolerated given alone or 6… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 13 extracted citations

Cyclooxygenase-2 in epilepsy.

Epilepsia • 2014
View 4 Excerpts
Highly Influenced

Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…