Nimesulide aggravates kainic acid-induced seizures in the rat.

@article{Kunz2001NimesulideAK,
  title={Nimesulide aggravates kainic acid-induced seizures in the rat.},
  author={Tina Kunz and Ernst H. Oliw},
  journal={Pharmacology & toxicology},
  year={2001},
  volume={88 5},
  pages={271-6}
}
Treatment of rats with kainic acid (10 mg/kg, intraperitoneally) triggers limbic seizures. Cyclooxygenase-2 mRNA is expressed in the hippocampus and cortex after 8 hr and marked cell loss occurs after 72 hr in the CA1-CA3 areas of the hippocampus. We examined the effect of the cyclooxygenase-2 inhibitor, nimesulide (N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide), on kainate-induced seizures and delayed neurotoxicity. Nimesulide (10 mg/kg, intraperitoneally) was well tolerated given alone or 6… CONTINUE READING

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