Nimesulide – a multifactorial approach to inflammation and pain: scientific and clinical consensus

@article{Rainsford2006NimesulideA,
  title={Nimesulide – a multifactorial approach to inflammation and pain: scientific and clinical consensus},
  author={Kim Drummond Rainsford},
  journal={Current Medical Research and Opinion},
  year={2006},
  volume={22},
  pages={1161 - 1170}
}
  • K. Rainsford
  • Published 16 May 2006
  • Medicine, Biology
  • Current Medical Research and Opinion
BACKGROUND This paper summarises the outcome from a consensus meeting, held in Rome on 5 October 2005, that aimed to review the state of the art regarding the non-steroidal anti-inflammatory drug (NSAID) nimesulide, with reference to its chemical, pharmacokinetic, pharmacological and clinical characteristics. [] Key Result Nimesulide was found to be at least as effective, or superior, to placebo and other NSAIDs, with a particularly fast onset of analgesic action. The safety profile is in line with that…
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Due to its multifactorial mechanism as well as to rapid onset of the analgesic action, nimesulide represents an appealing therapeutic choice for the treatment of rheumatology patients.
The Spectrum of Nimesulide-Induced-Hepatotoxicity. An Overview
TLDR
The clinical and histologic spectrum of nimesulide-associated-liver damage is described based on the comparison of the series of 43 cases and worldwide published observations in the pertinent medical literature.
[The use of nimesulide in the treatment of acute low back pain].
TLDR
The use of nemulex at a dose of 200 mg per day resulted in relief of pain and increase of mobility in the lumbar spine on the 5th day of treatment that indicates the effectiveness of anti-inflammatory therapy to restore the previous functional status of patients with LBP.
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TLDR
The article presents the findings of questionnaire-based survey on the use of non-steroidal anti-inflammatory drugs conducted by the Chelyabinsk practitioners, taking into account efficacy, safety and area of intended use.
nimesulide in the functional endoscopic sinus surgery
TLDR
Gabapentin or nimesulide may be safely used preemptively for the purposes of postoperative analgesia after FESS procedures, and total diclofenac consumption of group 2 was found to be significantly lower than Group 1 and Group 3 on a statistical basis.
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TLDR
Results confirm the antioxidative properties of the study drug, indicating that nimesulide, beside its known anti-inflammatory properties, also shows an evident antioxidative activity that adds further supportive evidence to its key role in the treatment of OA patients.
Toxicopathological overview of analgesic and anti-inflammatory drugs in animals
TLDR
Research relating to these adverse drug reactions, focusing on histopathological findings, which may contribute to the comprehension and possible avoidance of drug-induced disease is reviewed.
[Preemptive analgesic efficacy of gabapentin and nimesulide in the functional endoscopic sinus surgery].
TLDR
Gabapentin or nimesulide may be safely used preemptively for the purposes of postoperative analgesia after FESS procedures, and total diclofenac consumption of group 2 was found to be significantly lower than Group 1 and Group 3 on a statistical basis.
Enhanced analgesic activity by cyclodextrins – a systematic review and meta-analysis
TLDR
A systematic review to evaluate the analgesic activity of compounds complexed in cyclodextrins, analyzing whether these complexes improved analgesic efficacy found that the complexed drug had a significantly (p < 0.01) greater effect than the non-complexed drug.
The relatively selective cyclooxygenase‐2 inhibitor nimesulide: What's going on?
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TLDR
Nimesulide, similar to other nonsteroidal anti-inflammatory drugs (NSAIDs), has been associated with rare and unpredictable but serious hepatic adverse reactions, and it is suggested that the rare cases of liver injury may be caused by a metabolic idiosyncrasy.
Nimesulide and hepatic adverse effects: roles of reactive metabolites and host factors.
TLDR
Nimesulide, similar to other nonsteroidal anti-inflammatory drugs (NSAIDs), has been associated with rare and unpredictable but serious hepatic adverse reactions, and it is suggested that the rare cases of liver injury may be caused by a metabolic idiosyncrasy.
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