Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase

@article{Wu1993Nim1KP,
  title={Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase},
  author={L. Wu and P. Russell},
  journal={Nature},
  year={1993},
  volume={363},
  pages={738-741}
}
  • L. Wu, P. Russell
  • Published 1993
  • Biology, Medicine
  • Nature
  • IN most species, including the fission yeast Schizosaccharomyces pombe, the Cdc2/cyclin B mitosis-inducing kinase is maintained in an inhibited state during interphase as a result of phosphorylation of a tyrosine residue in the ATP-binding region of Cdc2 (refs 1–3). This site is phosphorylated by Wee1 kinase4–9 and dephosphorylated by Cdc25 phosphatase10–15. In fission yeast an additional element of the G2/M control Nim1/Cdr1 kinase, has been identified which functions as a potent mitotic… CONTINUE READING
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