Nilotinib in patients with GIST who failed imatinib and sunitinib: importance of prior surgery on drug bioavailability

@article{Kim2010NilotinibIP,
  title={Nilotinib in patients with GIST who failed imatinib and sunitinib: importance of prior surgery on drug bioavailability},
  author={Kyu-pyo Kim and Min-Hee Ryu and Changhoon Yoo and B Ryoo and Dae Ro Choi and Heung Moon Chang and J S Lee and Mo Youl Beck and Tae Won Kim and Yoon-koo Kang},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2010},
  volume={68},
  pages={285-291}
}
To evaluate the efficacy of nilotinib in patients with advanced gastrointestinal stromal tumors (GISTs) resistant or intolerant to both imatinib and sunitinib and to explore the potential relationship between nilotinib pharmacokinetics and clinical outcomes. We analyzed the efficacy, tolerability and pharmacokinetic parameters of nilotinib (400 mg twice daily) in 17 GIST patients with histories of prior gastrointestinal surgery. Median patient age was 59 years (range, 35–71 years), 14 of 17… CONTINUE READING

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