Nigrostriatal function in vitamin E deficiency: clinical, experimental, and positron emission tomographic studies.

@article{Dexter1994NigrostriatalFI,
  title={Nigrostriatal function in vitamin E deficiency: clinical, experimental, and positron emission tomographic studies.},
  author={David T Dexter and David J. Brooks and Anita E. Harding and David J. Burn and David P. R. Muller and M A Goss-Sampson and Peter Jenner and C. David Marsden},
  journal={Annals of neurology},
  year={1994},
  volume={35 3},
  pages={298-303}
}
Four patients with vitamin E deficiency and sensory ataxia were studied using [18F]dopa positron emission tomography. The 2 most disabled patients, who had severe and prolonged vitamin E deficiency due to abetalipoproteinemia, showed reduced [18F]dopa uptake in both putamen and caudate. Putaminal uptake was in a similar range to that seen in Parkinson's disease. Studies of [3H]mazindol binding in the striatum of vitamin E--deficient rats indicated a reduced number of dopamine terminals, which… CONTINUE READING
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