Nigrostriatal function in humans studied with positron emission tomography

@article{Martin1989NigrostriatalFI,
  title={Nigrostriatal function in humans studied with positron emission tomography},
  author={W. Martin and M. Palmer and C. Patlak and D. Calne},
  journal={Annals of Neurology},
  year={1989},
  volume={26}
}
The dopamine depletion that is characteristic of Parkinson's disease has been hypothesized to result from the combination of environmentally induced subclinical damage to the substantia nigra and the age‐related loss of additional nigral neurons. Essential to this hypothesis is the existence of deteriorating function in the nigrostriatal pathway with advancing age. The present study was undertaken with [18F]6‐fluoro‐L‐dopa and positron emission tomography to determine in vivo the effects of age… Expand
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