Nigral D1 and striatal D2 receptors mediate the behavioral effects of dopamine agonists.

@article{Lahoste1990NigralDA,
  title={Nigral D1 and striatal D2 receptors mediate the behavioral effects of dopamine agonists.},
  author={Gerald J Lahoste and John Marshall},
  journal={Behavioural brain research},
  year={1990},
  volume={38 3},
  pages={233-42}
}
The mediation of behavior by nigral and striatal dopamine (DA) D1 and D2 receptors was investigated in rats that had sustained extensive unilateral 6-hydroxydopamine-induced injury to ascending DA neurons. Selective D1 and D2 agonists and antagonists were injected directly into the DA-denervated substantia nigra pars reticula or the caudate-putamen via a chronically indwelling cannula. Contralateral rotation resulting from unilateral stimulation of supersensitive DA receptors was quantified… CONTINUE READING

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