Nightshift work and genome-wide DNA methylation.

  title={Nightshift work and genome-wide DNA methylation.},
  author={P. K. Bhatti and Yuzheng Zhang and Xiaoling Song and Karen W. Makar and Cassandra L. Sather and Karl T. Kelsey and E. Andres Houseman and Pei Wang},
  journal={Chronobiology international},
  volume={32 1},
The negative health effects of shift work, including carcinogenesis, may be mediated by changes in DNA methylation, particularly in the circadian genes. Using the Infinium HumanMethylation450 Bead Array (Illumina, San Diego, CA), we compared genome-wide methylation between 65 actively working dayshift workers and 59 actively working nightshift workers in the healthcare industry. A total of 473 800 loci, including 391 loci across the 12 core circadian genes, were analyzed to identify methylation… CONTINUE READING