Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver

@article{Kudo2004NighttimeRF,
  title={Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver},
  author={Takashi Kudo and Masaru Akiyama and Kouji Kuriyama and Makoto Sudo and Takuya Moriya and Shigenobu Shibata},
  journal={Diabetologia},
  year={2004},
  volume={47},
  pages={1425-1436}
}
An increase in PAI-1 activity is thought to be a key factor underlying myocardial infarction. Mouse Pai-1 (mPai-1) activity shows a daily rhythm in vivo, and its transcription seems to be controlled not only by clock genes but also by humoral factors such as insulin and triglycerides. Thus, we investigated daily clock genes and mPai-1 mRNA expression in the liver of db/db mice exhibiting high levels of glucose, insulin and triglycerides. Locomotor activity was measured using an infrared… CONTINUE READING

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