Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6.

@article{Dryja2005NightBA,
  title={Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6.},
  author={T. P. Dryja and T. L. McGee and Eliot L. Berson and Gerald Allen Fishman and Michael A. Sandberg and Kenneth R. Alexander and Deborah J. Derlacki and Aruna S. Rajagopalan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 13},
  pages={4884-9}
}
We report three unrelated patients with mutations in the GRM6 gene that normally encodes the glutamate receptor mGluR6. This neurotransmitter receptor has been shown previously to be present only in the synapses of the ON bipolar cell dendrites, and it mediates synaptic transmission from rod and cone photoreceptors to this type of second-order neuron… CONTINUE READING