Nigericin and grisorixin methyl ester from the Algerian soil-living Streptomyces youssoufiensis SF10 strain: a computational study on their epimeric structures and evaluation of glioblastoma stem cells growth inhibition

@article{Leulmi2019NigericinAG,
  title={Nigericin and grisorixin methyl ester from the Algerian soil-living Streptomyces youssoufiensis SF10 strain: a computational study on their epimeric structures and evaluation of glioblastoma stem cells growth inhibition},
  author={Nassima Leulmi and Denise Sighel and Andreas Defant and Karima Khenaka and Abderrahmane Boulahrouf and Ines Mancini},
  journal={Natural Product Research},
  year={2019},
  volume={33},
  pages={266 - 273}
}
Abstract The present work describes the metabolites produced by a strain identified as Streptomyces youssoufiensis, whose secondary metabolites profile has not been studied so far. The crude ethyl acetate extract was analyzed by high performance liquid chromatography-electrospray ionization mass spectrometry, leading to the detection of the ionophoric polyethers nigericin, epinigericin, abierixin and the newly isolated grisorixin methyl ester. The presence of epimeric forms of nigericin… 
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Enhanced Production and Quantitative Evaluation of Nigericin from the Algerian Soil-Living Streptomyces youssoufiensis SF10 Strain
TLDR
The HPLC-ELSD method, optimized here for the quantitative detection of nigericin, can find wider applications in the analysis of several other metabolites characterized by a similar polycyclic polyether structure or, more generally, by the lack of significant chromophores in their molecular structure.
Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules
TLDR
Focusing on the Algerian natural sources of antimicrobial metabolites, this work is a representative example of the potential of a closely combined study on biology and chemistry of natural products.
Bioactive compounds of Streptomyces: Biosynthesis to applications
Evidence of nigericin as a potential therapeutic candidate for cancers: A review.
Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives.
Emerging strategies for microbial screening of novel chemotherapeutics

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