Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa.

Abstract

The rare indazole-type alkaloid nigellidine (2) is accompanied by its 4-O-sulfite (4) in the seeds of Nigella sativa. Compound 4 may represent the true natural product leading to nigellidine (2) via hydrolysis of the sulfate functionality during the isolation process. The structure of nigellidine-4-O-sulfite (4) is confirmed by NMR, MS, and X-ray crystallographic data. This is the first report of the natural occurrence of sulfated indazole-type alkaloids.

DOI: 10.1021/np800172x

Cite this paper

@article{Ali2008Nigellidine4OsulfiteTF, title={Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa.}, author={Zulfiqar Ali and Daneel Ferreira and Paulo B. Carvalho and Mitchell A. Avery and Ikhlas Ahmad Khan}, journal={Journal of natural products}, year={2008}, volume={71 6}, pages={1111-2} }