Nigella sativa amliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats.
@article{Noor2015NigellaSA, title={Nigella sativa amliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats.}, author={Neveen A. Noor and Heba Mohamed Fahmy and Faten F Mohammed and Anwar A. Elsayed and Nasr Mahmoud Radwan}, journal={International journal of clinical and experimental pathology}, year={2015}, volume={8 6}, pages={ 6269-86 } }
Multiple sclerosis (MS) is the major, immune-mediated, demyelinating neurodegenerative disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model of MS. The aim of the present study was to investigate the protective and ameliorative effects of N. sativa seeds (2.8 g/kg body weight) in EAE-induced Wistar rats. EAE-induced rats were divided into: 1- EAE-induced rats ("EAE" group). 2- "N. sativa + EAE" group received daily oral…
33 Citations
Effects of Tripterygium glycoside treatment on experimental autoimmune encephalomyelitis.
- Biology, MedicineMolecular medicine reports
- 2017
TTP effectively inhibited EAE via the inhibition of CNS inflammatory cell infiltration, enhancement of inflammatory cell apoptosis, and downregulation of the expression of NF‑κB and IL‑2.
Effect Nigella sativa extract for balancing immune response in pristane induced lupus mice model
- Biology
- 2020
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with wide manifestations that require long-term treatment. Current treatment has not shown a satisfying result and still yields some…
Cannabis-induced Moto-Cognitive Dysfunction in Wistar Rats: Ameliorative Efficacy of Nigella Sativa.
- Biology, PsychologyThe Malaysian journal of medical sciences : MJMS
- 2016
The observed ameliorative effects of NSO make it a promising agent against moto-cognitive dysfunction and cerebelo-hippocampal alterations induced by cannabis.
Anti-LINGO-1 improved remyelination and neurobehavioral deficit in cuprizone-induced demyelination
- Biology, PsychologyIranian journal of basic medical sciences
- 2021
Evidence is provided that LINGO-1 antibody can improve remyelination and neurobehavioral deficit in multiple sclerosis and motor impairment was significantly improved in the treatment group.
Subchronic dichlorvos-induced Cardiotoxicity in Wistar rats: Mitigative efficacy of Nigella sativa oil
- Medicine, Biology
- 2018
It can be concluded that NSO was able to attenuate DDVP-induced cardiotoxicity and increase the plasma levels of TC, LDL, atherogenic and atherosclerotic indices, but this was prevented by co-administration with NSO.
Dichlorvos Induced AChE Inhibition in Discrete Brain Regions and the Neuro-Cognitive Implications: Ameliorative Effect of Nigella Sativa
- Biology, MedicineIranian Journal of Toxicology
- 2018
It is concluded that NSO reactivated DDVP-induced AChE inhibition and improved memory indices, thus, it may serve as a potential treatment in the management of DDVP poisoning cases.
Medicinal herbs and multiple sclerosis: Overview on the hard balance between new therapeutic strategy and occupational health risk
- BiologyFrontiers in Cellular Neuroscience
- 2022
A glance at the therapeutic potential of medicinal plants and at the risk for MS onset of pesticides used by medicinal plant growers and present in medicinal herbs is provided.
IN VIVO AND IN VITRO EFFICACY OF NIGELLA SATIVA AQUEOUS EXTRACT ON BLASTOCYSTIS HOMINIS.
- Medicine, BiologyJournal of the Egyptian Society of Parasitology
- 2016
Present study proved that N. sativa had inhibitory effect on B. hominis in vitro and prevented cytopathic effect in infected mice inoculated orally with B.hominis.
The Role of Natural Products in the Prevention and Treatment of Multiple Sclerosis
- Biology, Medicine
- 2017
Nigella sativa: Valuable perspective in the management of chronic diseases
- MedicineIranian journal of basic medical sciences
- 2020
In vivo and in vitro studies demonstrated N. sativa positive effect against diabetes, hypertension, and hypercholesterolemia, all of them associated to cardiovascular diseases progression.
References
SHOWING 1-10 OF 111 REFERENCES
Amelioration of chronic relapsing experimental autoimmune encephalomyelitis (cr-eae) using thymoquinone - biomed 2009.
- Biology, MedicineBiomedical sciences instrumentation
- 2009
Preliminary result showed that TQ due to its antioxidant effect is almost 90% preventive and 50% curative in CR-EAE, which could assist further studies on the mechanism of action of TQ and explore the possibility of treating the human chronic relapsing multiple sclerosis phase.
Improvement of experimental allergic encephalomyelitis (EAE) by thymoquinone; an oxidative stress inhibitor.
- Biology, MedicineBiomedical sciences instrumentation
- 2003
Thymoquinone inhibited oxidative stress which leads into improvement in EAE animals, and may have a role in treatment of Multiple Sclerosis.
Thymoquinone inhibits the activation of NF-kappaB in the brain and spinal cord of experimental autoimmune encephalomyelitis.
- Biology, MedicineBiomedical sciences instrumentation
- 2005
Treatment of rats with thymoquinone 1 mg/kg/day concomitant to myelin basic protein and after the appearance of clinical signs resulted in preventing and ameliorating experimental autoimmune encephalomyelitis.
Clinical course of myelin oligodendrocyte glycoprotein 35–55 induced experimental autoimmune encephalomyelitis is aggravated by glia maturation factor
- BiologyNeurochemistry International
- 2012
Chronologic neuropathology of relapsing experimental allergic encephalomyelitis in the mouse.
- Biology, MedicineLaboratory investigation; a journal of technical methods and pathology
- 1982
Since the mouse is a highly accessible species that is immunologically well understood, this model might lend itself to fuller dissection of autoimmune events associated with recurrent demyelination, problems of considerable significance to multiple sclerosis research.
Experimental allergic encephalomyelitis: Neutralizing antibody to TGFβ1 enhances the clinical severity of the disease
- Biology, MedicineJournal of Neuroimmunology
- 1993
Protective effects of caffeic acid phenethyl ester against experimental allergic encephalomyelitis-induced oxidative stress in rats.
- BiologyFree radical biology & medicine
- 2004
Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis.
- BiologyJournal of neurovirology
- 1999
Results indicate that IP-10 is dependent upon IFN-gamma for its upregulation during this model disease, and document directly that astrocyte expression of chemokines during EAE is governed by pro-inflammatory cytokines.
Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats
- Biology, MedicineHuman & experimental toxicology
- 2006
In conclusion, NS treatment might be beneficial in spinal cord tissue damage, and therefore shows potential for clinical implications.