Corpus ID: 1984790

Nigella sativa amliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats.

@article{Noor2015NigellaSA,
  title={Nigella sativa amliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats.},
  author={N. A. Noor and H. Fahmy and F. F. Mohammed and A. Elsayed and N. M. Radwan},
  journal={International journal of clinical and experimental pathology},
  year={2015},
  volume={8 6},
  pages={
          6269-86
        }
}
Multiple sclerosis (MS) is the major, immune-mediated, demyelinating neurodegenerative disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model of MS. The aim of the present study was to investigate the protective and ameliorative effects of N. sativa seeds (2.8 g/kg body weight) in EAE-induced Wistar rats. EAE-induced rats were divided into: 1- EAE-induced rats ("EAE" group). 2- "N. sativa + EAE" group received daily oral… Expand
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Effects of Tripterygium glycoside treatment on experimental autoimmune encephalomyelitis.
TLDR
TTP effectively inhibited EAE via the inhibition of CNS inflammatory cell infiltration, enhancement of inflammatory cell apoptosis, and downregulation of the expression of NF‑κB and IL‑2. Expand
Effect Nigella sativa extract for balancing immune response in pristane induced lupus mice model
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with wide manifestations that require long-term treatment. Current treatment has not shown a satisfying result and still yields some… Expand
Cannabis-induced Moto-Cognitive Dysfunction in Wistar Rats: Ameliorative Efficacy of Nigella Sativa.
TLDR
The observed ameliorative effects of NSO make it a promising agent against moto-cognitive dysfunction and cerebelo-hippocampal alterations induced by cannabis. Expand
Subchronic dichlorvos-induced Cardiotoxicity in Wistar rats: Mitigative efficacy of Nigella sativa oil
TLDR
It can be concluded that NSO was able to attenuate DDVP-induced cardiotoxicity and increase the plasma levels of TC, LDL, atherogenic and atherosclerotic indices, but this was prevented by co-administration with NSO. Expand
Dichlorvos Induced AChE Inhibition in Discrete Brain Regions and the Neuro-Cognitive Implications: Ameliorative Effect of Nigella Sativa
TLDR
It is concluded that NSO reactivated DDVP-induced AChE inhibition and improved memory indices, thus, it may serve as a potential treatment in the management of DDVP poisoning cases. Expand
Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19
TLDR
Preliminary data of molecular docking, animal, and clinical studies propose N. sativa and TQ might have beneficial effects on the treatment or control of COVID-19 due to antiviral, anti-inflammatory and immunomodulatory properties as well as bronchodilatory effects. Expand
Comparative study of the possible protective effect of thymoquinone (black seeds) when compared with vitamin E on acrylamide-induced neurotoxicity in the adult guinea pig cerebellar cortex
TLDR
It is proved that the neurotoxicity induced by ACR can be alleviated by combined treatment with vitamin E or TQ and displayed an observable protection against these changes. Expand
IN VIVO AND IN VITRO EFFICACY OF NIGELLA SATIVA AQUEOUS EXTRACT ON BLASTOCYSTIS HOMINIS.
TLDR
Present study proved that N. sativa had inhibitory effect on B. hominis in vitro and prevented cytopathic effect in infected mice inoculated orally with B.hominis. Expand
The Role of Natural Products in the Prevention and Treatment of Multiple Sclerosis
TLDR
A brief list of the natural compounds that have been reported as effective in the treatment of MS in basic and clinical studies is prepared, which includes selected flavonoids, phytoestrogens, alkaloids, triterpenes, polysaccharides, bee venom, and some herbs. Expand
Nigella sativa: Valuable perspective in the management of chronic diseases
TLDR
In vivo and in vitro studies demonstrated N. sativa positive effect against diabetes, hypertension, and hypercholesterolemia, all of them associated to cardiovascular diseases progression. Expand
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