Corpus ID: 1984790

Nigella sativa amliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats.

@article{Noor2015NigellaSA,
  title={Nigella sativa amliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats.},
  author={N. A. Noor and H. Fahmy and F. F. Mohammed and A. Elsayed and N. M. Radwan},
  journal={International journal of clinical and experimental pathology},
  year={2015},
  volume={8 6},
  pages={
          6269-86
        }
}
Multiple sclerosis (MS) is the major, immune-mediated, demyelinating neurodegenerative disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model of MS. The aim of the present study was to investigate the protective and ameliorative effects of N. sativa seeds (2.8 g/kg body weight) in EAE-induced Wistar rats. EAE-induced rats were divided into: 1- EAE-induced rats ("EAE" group). 2- "N. sativa + EAE" group received daily oral… Expand
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References

SHOWING 1-10 OF 112 REFERENCES
Nigella sativa as an anti-inflammatory and promising remyelinating agent in the cortex and hippocampus of experimental autoimmune encephalomyelitis-induced rats
TLDR
N. sativa seeds could be used as a protective agent or an adjunct treatment for EAE even when the treatment started after the appearance of the first clinical signs, but the dose and duration must be taken into consideration to avoid its probable pro-oxidant effect. Expand
Amelioration of chronic relapsing experimental autoimmune encephalomyelitis (cr-eae) using thymoquinone - biomed 2009.
TLDR
Preliminary result showed that TQ due to its antioxidant effect is almost 90% preventive and 50% curative in CR-EAE, which could assist further studies on the mechanism of action of TQ and explore the possibility of treating the human chronic relapsing multiple sclerosis phase. Expand
Improvement of experimental allergic encephalomyelitis (EAE) by thymoquinone; an oxidative stress inhibitor.
TLDR
Thymoquinone inhibited oxidative stress which leads into improvement in EAE animals, and may have a role in treatment of Multiple Sclerosis. Expand
The effect of Nigella sativa oil against experimental allergic encephalomyelitis via nitric oxide and other oxidative stress parameters.
TLDR
N sativa components provide protection against oxidative stress induced by experimental autoimmune encephalomyelitis (EAE) in rats and display its antioxidant and regulatory effects via inflammatory cells rather than the host tissue (brain and medulla spinalis) for EAE in rats. Expand
Thymoquinone inhibits the activation of NF-kappaB in the brain and spinal cord of experimental autoimmune encephalomyelitis.
TLDR
Treatment of rats with thymoquinone 1 mg/kg/day concomitant to myelin basic protein and after the appearance of clinical signs resulted in preventing and ameliorating experimental autoimmune encephalomyelitis. Expand
Clinical course of myelin oligodendrocyte glycoprotein 35–55 induced experimental autoimmune encephalomyelitis is aggravated by glia maturation factor
TLDR
GMF-KO mice were resistant to the MOG 35-55 peptide-induced experimental autoimmune encephalomyelitis (EAE) as compared to wild type (Wt) mice, and the reconstitution experiment showed that the administration of rGMF produced significant increase in the GMF-mediated cytokine/chemokine production. Expand
Chronologic neuropathology of relapsing experimental allergic encephalomyelitis in the mouse.
TLDR
Since the mouse is a highly accessible species that is immunologically well understood, this model might lend itself to fuller dissection of autoimmune events associated with recurrent demyelination, problems of considerable significance to multiple sclerosis research. Expand
Experimental allergic encephalomyelitis: Neutralizing antibody to TGFβ1 enhances the clinical severity of the disease
TLDR
It is shown that the addition of anti-TGF beta 1 to myelin basic protein (MBP)-activated lymph node cells enhance the T cell proliferative response by 28% in vitro and in vivo and that injections ofAnti-T GF beta 1 antibody worsen EAE both in incidence and severity. Expand
Protective effects of caffeic acid phenethyl ester against experimental allergic encephalomyelitis-induced oxidative stress in rats.
TLDR
Treatment with CAPE significantly inhibited reactive oxygen species production induced by EAE, and ameliorated clinical symptoms in rats, suggesting that CAPE may exert its anti-inflammatory effect by inhibiting ROS production at the transcriptional level through the suppression of nuclear factor kappaB activation, and by directly inhibiting the catalytic activity of inducible nitric oxide synthase. Expand
Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis.
TLDR
Results indicate that IP-10 is dependent upon IFN-gamma for its upregulation during this model disease, and document directly that astrocyte expression of chemokines during EAE is governed by pro-inflammatory cytokines. Expand
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