Niflumic and flufenamic acids are potent inhibitors of chloride secretion in mammalian airway.

Abstract

Effects of niflumic acid (NFA) and flufenamic acid (FFA), the two nonsteroid anti-inflammatory agents recently reported to inhibit Cl- current in Xenopus oocytes, were examined in cultured monolayers of dog and cow trachea. Both agents showed potent inhibition to the short-circuit current (Isc), an index of magnitude of transepithelial Cl- secretion, with values of Ki of 0.02 (for NFA) and 0.06 (for FFA) mM, respectively. The sensitivity sequence of Isc to the Cl- channel inhibitors tested was NFA > FFA > diphenylamine-2-carboxylate (DPC) >> anthracene-9-carboxylate (A9C). Thus, NFA and FFA are so far the most potent commercially available Cl- channel inhibitors tested in Cl(-)-secreting epithelia. The sensitivity sequence of 36Cl uptake to the above Cl- channel inhibitors in Xenopus laevis oocytes was found to be identical to the cultures of trachea. This seems to imply that the membrane Cl- channels of Xenopus oocytes are functionally similar to that identified in mammalian Cl(-)-secreting epithelia.

Statistics

0100200'95'97'99'01'03'05'07'09'11'13'15'17
Citations per Year

545 Citations

Semantic Scholar estimates that this publication has 545 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Chao1992NiflumicAF, title={Niflumic and flufenamic acids are potent inhibitors of chloride secretion in mammalian airway.}, author={Angela Chueh Chao and Hideki Mochizuki}, journal={Life sciences}, year={1992}, volume={51 18}, pages={1453-7} }