Niflumic acid activates additional currents of the human glial L-glutamate transporter EAAT1 in a substrate-dependent manner.

@article{Takahashi2013NiflumicAA,
  title={Niflumic acid activates additional currents of the human glial L-glutamate transporter EAAT1 in a substrate-dependent manner.},
  author={Kanako Takahashi and R. Ishii-Nozawa and Koichi Takeuchi and K. Nakazawa and Y. Sekino and K. Sato},
  journal={Biological & pharmaceutical bulletin},
  year={2013},
  volume={36 12},
  pages={
          1996-2004
        }
}
The astrocytic L-glutamate (L-Glu) transporter EAAT1 participates in the removal of L-Glu from the synaptic cleft and maintenance of non-toxic concentrations in the extracellular fluid. We have shown that niflumic acid (NFA), a non-steroidal anti-inflammatory drug (NSAIDs), alters L-Glu-induced EAAT1 currents in a voltage-dependent manner using the two-electrode voltage clamp technique in Xenopus oocytes expressing EAAT1. In this study, we characterised the effects of NFA on each type of ion… Expand
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