Nifedipine prevents sodium caprate-induced barrier dysfunction in human epidermal keratinocyte cultures.

Abstract

Tight junctions (TJs) of the epidermis play an important role in maintaining the epidermal barrier. TJ breakdown is associated with skin problems, such as wrinkles and transepidermal water loss (TEWL). Clinical studies have reported that topical nifedipine is effective in reducing the depth of wrinkles and improving TEWL. However, it remains unknown whether… (More)
DOI: 10.1248/bpb.b14-00854

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Cite this paper

@article{Uchino2015NifedipinePS, title={Nifedipine prevents sodium caprate-induced barrier dysfunction in human epidermal keratinocyte cultures.}, author={Yoshihiro Uchino and Junichi Matsumoto and Takuya Watanabe and Masato Hamabashiri and Takashi Tsuchiya and Ikuya Kimura and Atsushi Yamauchi and Yasuhumi Kataoka}, journal={Biological & pharmaceutical bulletin}, year={2015}, volume={38 6}, pages={926-9} }