Nifedipine inhibits sphingosine-1-phosphate-induced renovascular contraction in vitro and in vivo

@article{Bischoff2001NifedipineIS,
  title={Nifedipine inhibits sphingosine-1-phosphate-induced renovascular contraction in vitro and in vivo},
  author={Angela Bischoff and J. Finger and Martin C Michel},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2001},
  volume={364},
  pages={179-182}
}
Sphingosine-1-phosphate (SPP) can constrict isolated intrarenal blood vessels in vitro and reduce renal blood flow in vivo. The present study has investigated the role of extracellular Ca2+ and dihydropyridine-sensitive Ca2+ channels in SPP-induced renovascular contraction. In isolated intrarenal microvessels, cumulative addition of SPP (0.1–100 µM) caused concentration-dependent vasoconstriction (maximum effect 5.0±1.1 mN). In the presence of nifedipine (300 nM, added 30 min before SPP) or… CONTINUE READING

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