Nifedipine does not induce but rather prevents apoptosis in cardiomyocytes.

  title={Nifedipine does not induce but rather prevents apoptosis in cardiomyocytes.},
  author={Simon W. Rabkin and Jennifer Y. Kong},
  journal={European journal of pharmacology},
  volume={388 3},
The potential of Ca(2+) channel antagonists, particularly nifedipine, to cause apoptotic cell death has been controversial and is of considerable importance for cardiomyocytes as loss of these cells is an important component of the pathophysiology leading to heart failure. To examine the hypothesis that nifedipine induces cell death and modulates calcium-induced apoptosis, cardiomyocytes in culture from embryonic chick hearts, that readily manifest apoptosis, were studied. Apoptosis was… CONTINUE READING