Nifedipine Compared With Atosiban for Treating Preterm Labor: A Randomized Controlled Trial

@article{Salim2012NifedipineCW,
  title={Nifedipine Compared With Atosiban for Treating Preterm Labor: A Randomized Controlled Trial},
  author={Raed Salim and Gali Garmi and Zohar Nachum and Noah Zafran and Shira Baram and Eliezer Shalev},
  journal={Obstetrics \& Gynecology},
  year={2012},
  volume={120},
  pages={1323–1331}
}
OBJECTIVE: To compare the tocolytic efficacy and tolerability of nifedipine with that of atosiban among pregnant women with preterm labor. METHODS: Pregnant women admitted with preterm labor and intact membranes between 24 and 33 weeks 6 days of gestation, between January 2008 and December 2011, were randomly assigned to either atosiban or nifedipine treatment. Assigned treatment was planned for up to 48 hours. If progress was determined after 1 hour or more, a crossover of the study drugs was… 
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In patients with threatened preterm birth, 48 hour tocolysis with atosiban was found to be safe and effective in preventing imminent pre term birth even when it was a twin pregnancy or associated with co-morbidities.
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Nifedipine had a higher success rate for inhibiting threatened preterm contractions compared with a placebo group, and delivered within 48 hours compared with 12.6% in the placebo group.
Nifedipine versus atosiban in the treatment of threatened preterm labour (Assessment of Perinatal Outcome after Specific Tocolysis in Early Labour: APOSTEL III-Trial)
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This multicenter randomised clinical trial aims to compare nifedipine and atosiban in terms of neonatal outcome, duration of pregnancy and maternal side effects, and provide evidence on the optimal drug of choice in acute tocolysis in threatening preterm labour.
Short-Term Outcomes of Atosiban in the Treatment of Preterm Labour at the Sultan Qaboos University Hospital, Muscat, Oman
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Atosiban was highly effective in delaying delivery by ≥48 hours and resulted in few adverse maternal side-effects and neonatal outcomes, to the best of the authors’ knowledge.
Atosiban efficacy and safety in pregnant women with threatened preterm delivery : systematic review of the literature with network meta-analysis
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Atosiban has similar efficacy for delivery delay in patients with risk of preterm delivery as compared to other agents, showing some advantages regarding neonatal mortality (low certainty) versus indomethacin, and compared to fenoterol, nifedipine and terbutaline in terms of maternal adverse events (moderate certainty).
Atosiban Combined with Ritodrine for Late Threatened Abortion or Threatened Premature Labor Patients with No Response to Ritodrine: A Clinical Trial
  • S. Fu, Haitian Xie, Jian-ping Tan
  • Medicine
    Medical science monitor : international medical journal of experimental and clinical research
  • 2021
TLDR
Ritodrine combined with atosiban extends gestation and improves pregnancy outcomes and for patients with abnormal uterine contractions, routine testing for reproductive tract infection should be performed.
Oxytocin receptor antagonists for inhibiting preterm labour.
TLDR
ORA resulted in a small reduction in birthweight and an increase in maternal adverse drug reactions requiring cessation of treatment in comparison with placebo, but no differences were shown in preterm birth less than 37 weeks' gestation or any other adverse neonatal outcomes.
Pregnancy and neonatal outcomes of hyperglycemia caused by atosiban administration during pregnancy
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Atosiban administration in pregnant women results in significantly elevated maternal blood glucose, which results in hypoglycemia in neonates a ter birth, therefore, neonates from mothers who received atosiban require a blood glucose test and close monitoring of newborns.
Preterm labor: current pharmacotherapy options for tocolysis
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An overview of current pharmacological therapies for preterm labor is provided to provide an overview of tocolytics and the role of progesterone in treatment of acute to colysis is limited, but it might play a role in the prevention of pre term labor or as sensitizer for other tocoeltic agents.