• Corpus ID: 31657407

Nif 1 , a novel mitotic inhibitor in Schizosaccharomyces pombe ent of the Wee 1 – Mik 1 pair , as shown by the observation

  title={Nif 1 , a novel mitotic inhibitor in Schizosaccharomyces pombe ent of the Wee 1 – Mik 1 pair , as shown by the observation},
  author={Lin Wu and Paul Russell},
ent of the Wee1–Mik1 pair, as shown by the observation Lin Wu and Paul Russell1 that wee1– mutants have a wee phenotype (Nurse, 1975), Departments of Molecular Biology and Cell Biology, The Scripps undergoing mitosis and cell division at half the length of Research Institute, 10666 North Torrey Pines Road, La Jolla, wild type, whereas the mik1– mutation has no effect on CA 92037, USA cell size (Lundgren et al., 1991). However, simultaneous 1Corresponding author inactivation of wee1 and mik1… 

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Sizing up to divide: mitotic cell-size control in fission yeast.
  • E. Wood, P. Nurse
  • Biology
    Annual review of cell and developmental biology
  • 2015
This work has shown that fission yeast cells do not grow in a simple linear fashion, they require a size-sensing mechanism, and current models do not fully describe all aspects of this control, especially the coordination of cell size with ploidy.


cdc25 + functions as an inducer in the mitotic control of fission yeast
Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase
Observations show that Nim1 promotes the onset of mitosis by inhibiting Wee1, and Wee1 is hyperphosphorylated in cells that overproduce Nim1.
Phosphorylation and inactivation of the mitotic inhibitor Weel by the nim1/cdr1 kinase
Results show that nim1/cdr1 functions as a positive regulator of mitosis by directly phosphorylating and inactivating the mitotic inhibitor Weel.
Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase
The wee1+ gene product is representative of a novel class of protein kinase that phosphorylates both serine and tyrosine residues, and also phosphorylate an exogenous substrate, angiotensin II, on tyosine.
Spatial organization of the Nim1-Wee1-Cdc2 mitotic control network in Schizosaccharomyces pombe.
It is proposed that the intracellular distribution of Nim1 and Wee1 may serve to coordinate the regulation of nuclear Cdc2-Cdc13 with cytoplasmic growth.
Conservation of mitotic controls in fission and budding yeasts
Molecular genetic analysis of fission yeast Schizosaccharomyces pombe.
Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast
It is reported here that a fission yeast MAP kinase pathway links the cell-cycle G2/M control with changes in the extracellular environment that affect cell physiology.
Cell cycle regulation of human WEE1.
Antibody depletion experiments demonstrate that WEE1 accounts for most of the activity that phosphorylates CDC2 on Tyr15 in an in vitro assay of HeLa cell lysates, hence it is likely to have an important role in the mitotic control of human cells.