Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

@inproceedings{Tsuji2017NiemannPickTC,
  title={Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole},
  author={Takuma Tsuji and Megumi Fujimoto and Tsuyako Tatematsu and Jinglei Cheng and Minami Orii and Sho Takatori and Toyoshi Fujimoto},
  booktitle={eLife},
  year={2017}
}
Niemann-Pick type C is a storage disease caused by dysfunction of NPC proteins, which transport cholesterol from the lumen of lysosomes to the limiting membrane of that compartment. Using freeze fracture electron microscopy, we show here that the yeast NPC orthologs, Ncr1p and Npc2p, are essential for formation and expansion of raft-like domains in the vacuolar (lysosome) membrane, both in stationary phase and in acute nitrogen starvation. Moreover, the expanded raft-like domains engulf lipid… CONTINUE READING
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