Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo

@inproceedings{Herbert2015NiemannPickCI,
  title={Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo},
  author={Andrew S Herbert and Cristin Davidson and Ana I. Kuehne and Russell Bakken and Stephen Z. Braigen and Kathryn Elaine Gunn and Sean P J Whelan and Thijn R Brummelkamp and Nancy A. Twenhafel and Kartik Chandran and Steven U Walkley and John M Dye},
  booktitle={mBio},
  year={2015}
}
UNLABELLED Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus entry requirements of NPC1 in vitro, its roles in filovirus replication and pathogenesis in vivo remain unclear. Here, we evaluated the importance of NPC1, and its partner in cholesterol transport, NPC2, by using a mouse model of Ebolavirus (EBOV) disease. We found that, whereas wild-type mice had high viral loads and succumbed… CONTINUE READING

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