Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis.

@article{Feng2003NiemannPickCH,
  title={Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis.},
  author={Bo Feng and Dajun Zhang and George Kuriakose and Cecillia M Devlin and Mark Kockx and Ira Tabas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 18},
  pages={10423-8}
}
Macrophage death in advanced atherosclerotic lesions leads to lesional necrosis and likely promotes plaque instability, a precursor of acute vascular events. Macrophages in advanced lesions accumulate large amounts of unesterified cholesterol, which is a potent inducer of macrophage apoptosis. We have shown recently that induction of apoptosis in cultured macrophages requires cholesterol trafficking to the endoplasmic reticulum (ER). Moreover, macrophages from mice with a heterozygous mutation… CONTINUE READING

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