Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission.

  title={Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission.},
  author={Kristofer A. Radcliffe and John A Dani},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={18 18},
Synaptic modulation and long-term synaptic changes are thought to be the cellular correlates for learning and memory (Madison et al., 1991; Aiba et al., 1994, Goda and Stevens, 1996). The hippocampus is a center for learning and memory that receives abundant cholinergic innervation and has a high density of nicotinic acetylcholine receptors (nAChRs) (Wada et al., 1989; Woolf, 1991). We report that stro ng, brief stimulation of nAChRs enhanced hippocampal glutamatergic synaptic transmission on… CONTINUE READING


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