Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb.

@article{Mechawar2004NicotinicRR,
  title={Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb.},
  author={Naguib Mechawar and Armen Saghatelyan and R{\'e}gis Grailhe and Linda Scoriels and Gilles Gheusi and M. M. Gabellec and Pierre-Marie Lledo and Jean-Pierre Changeux},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 26},
  pages={9822-6}
}
Cholinergic axons and nicotinic receptors are abundant in all layers of the olfactory bulb (OB), the main region of newborn neuron integration in the adult brain. Here, we report that the OB granule cell layer in mice lacking the predominant form of brain high-affinity nicotinic acetylcholine receptors (beta(2)(-/-) mice) displayed nearly 50% more newborn… CONTINUE READING