Nicotinic receptors on local circuit neurons in dentate gyrus: a potential role in regulation of granule cell excitability.

@article{Frazier2003NicotinicRO,
  title={Nicotinic receptors on local circuit neurons in dentate gyrus: a potential role in regulation of granule cell excitability.},
  author={Charles J. Frazier and Ben W. Strowbridge and Roger L Papke},
  journal={Journal of neurophysiology},
  year={2003},
  volume={89 6},
  pages={3018-28}
}
Although the dentate gyrus is one of the primary targets of septo-hippocampal cholinergic afferents, relatively little is known about the cholinergic physiology of neurons in the area. By combining whole cell patch-clamp recording with brief local application of exogenous agonists in horizontal slices, we found that there is robust expression of functional somatic alpha 7-containing nicotinic acetylcholine receptors (nAChRs) on molecular layer interneurons, hilar interneurons, and the… CONTINUE READING

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