Nicotinic receptors modulating ACh release in rat cortical synaptosomes: role of Ca2+ ions in their function and desensitization.

@article{Marchi1999NicotinicRM,
  title={Nicotinic receptors modulating ACh release in rat cortical synaptosomes: role of Ca2+ ions in their function and desensitization.},
  author={Mario Marchi and M Lupinacci and E Bernero and F Bergaglia and Maurizio Raiteri},
  journal={Neurochemistry international},
  year={1999},
  volume={34 4},
  pages={319-28}
}
Cholinergic nerve terminals in the central nervous system are endowed with both muscarinic and nicotinic autoreceptors, mediating inhibition, and enhancement of acetylcholine release, respectively. Exogenous acetylcholine inhibited the K+(15 mM)-evoked overflow of [3H]acetylcholine from superfused rat neocortical synaptosomes; however, in the presence of atropine, this muscarinic inhibition was reversed into a nicotinic potentiation when acetylcholine was added concomitantly with high-K+, but… CONTINUE READING