Nicotinic receptors in the habenulo-interpeduncular system are necessary for nicotine withdrawal in mice.

@article{Salas2009NicotinicRI,
  title={Nicotinic receptors in the habenulo-interpeduncular system are necessary for nicotine withdrawal in mice.},
  author={Ramiro Salas and Renea Sturm and Jim Boulter and Mariella de Biasi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 10},
  pages={
          3014-8
        }
}
In humans, tobacco withdrawal produces symptoms that contribute to the difficulty associated with smoking cessation. Nicotine withdrawal symptoms can also be observed in rodents. A major standing question is which nicotinic receptor subtypes and which areas of the brain are necessary for nicotine withdrawal to occur. Using knock-out mice, we previously showed that the beta4, but not the beta2 subunit of nicotinic acetylcholine receptors, is necessary for the somatic manifestations of nicotine… CONTINUE READING

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Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling.

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CITES BACKGROUND

Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
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