Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells.

@article{Berger1998NicotinicRA,
  title={Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells.},
  author={Fr{\'e}d{\'e}rique Berger and Fred H. Gage and Sukumar Vijayaraghavan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 17},
  pages={
          6871-81
        }
}
Nicotine has many effects on CNS functions, presumably through its action on neuronal nicotinic acetylcholine receptors (AChRs). One subclass of AChRs that binds the snake venom toxin alpha-bungarotoxin (alpha-Bgt-AChRs) has been shown to modulate neurotransmission in the brain. We now show that alpha-Bgt-AChR activation by low doses of nicotine results in apoptotic cell death of both primary and immortalized hippocampal progenitor cells. In HC2S2-immortalized hippocampal progenitors, nicotine… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 77 CITATIONS, ESTIMATED 46% COVERAGE

Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex.

  • The Journal of pharmacology and experimental therapeutics
  • 2002
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Cell-autonomous inhibition of alpha 7-containing nicotinic acetylcholine receptors prevents death of parasympathetic neurons during development.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2007
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Nicotine induces apoptosis in TM 3 mouse Leydig cells by

Khae-Hawn Kim Adviced, Dr. Chang-Ju Kim
  • 2002
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1999
2018

CITATION STATISTICS

  • 9 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 64 REFERENCES

degeneration in C . elegans

S Vijayaraghavan, PC Pugh, ZW Zhang, MM Rathouz, DK Berg
  • 1992
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Specific down-regulation of the alpha-bungarotoxin binding component on chick autonomic neurons by ciliary neuronotrophic factor.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1989
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL