Nicotinic receptor activation negatively modulates pro-inflammatory cytokine production in multiple sclerosis patients.

@article{Reale2015NicotinicRA,
  title={Nicotinic receptor activation negatively modulates pro-inflammatory cytokine production in multiple sclerosis patients.},
  author={Marcella Reale and Maria Giovanna di Bari and Marta di Nicola and C D'Angelo and Federica de Angelis and Lucia Velluto and Ada Maria Tata},
  journal={International immunopharmacology},
  year={2015},
  volume={29 1},
  pages={152-7}
}
Acetylcholine (ACh) and its receptors of muscarinic and nicotinic types are involved in the modulation of immune and inflammatory responses. In present work we have characterized the nicotinic receptors expression in PBMC of RR-MS patients and healthy donors (HD) and their ability to modulate pro-inflammatory cytokines. Here we report that the IL-1β e IL-17… CONTINUE READING