Nicotinic plant poisoning

@article{Schep2009NicotinicPP,
  title={Nicotinic plant poisoning},
  author={Leo J. Schep and Robin J Slaughter and D Michael G Beasley},
  journal={Clinical Toxicology},
  year={2009},
  volume={47},
  pages={771 - 781}
}
Introduction. A wide range of plants contain nicotinic and nicotinic-like alkaloids. Of this diverse group, those that have been reported to cause human poisoning appear to have similar mechanisms of toxicity and presenting patients therefore have comparable toxidromes. This review describes the taxonomy and principal alkaloids of plants that contain nicotinic and nicotinic-like alkaloids, with particular focus on those that are toxic to humans. The toxicokinetics and mechanisms of toxicity of… 

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References

SHOWING 1-10 OF 72 REFERENCES

Poisoning due to water hemlock

The ingestion of water hemlock can lead to serious complications that may be fatal, but prognosis is good, however, if prompt supportive care is provided, and treatment consists mainly of prompt airway management and seizure control.

Poison hemlock (Conium maculatum L.).

  • J. Vetter
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2004

Another death due to ingestion of Nicotiana glauca.

The case of a 43-year-old man found dead after apparently drinking a water extract of Nicotiana glauca further supports the view that, in the human, anabasine is considerably more toxic than nicotine.

Gas chromatographic determination of toxic quinolizidine alkaloids in blue cohosh Caulophyllum thalictroides (L.) Michx

Blue cohosh (Caulophyllum thalictroides (L.) Michx., Berberidaceae) is a North American perennial herb which is found as an ingredient in dietary supplement products in the United States. The plant

Fatal poisoning from Nicotiana glauca leaves: identification of anabasine by gas-chromatography/mass spectrometry.

A GC/MS method was used for the identification of anabasine as the main constituent in the leaves, food extract, blood, and the urine of the deceased and to establish its presence.

A fatal poisoning from Nicotiana glauca.

Anabasine, the major, highly toxic alkaloid of the shrub, Nicotiana glauca (tree tobacco) was subsequently identified in all body specimens examined using gas chromatography/mass spectrometry.

Determination of saponins and alkaloids in Caulophyllum thalictroides (blue cohosh) by high-performance liquid chromatography and evaporative light scattering detection.

An HPLC method has been developed which permits the determination of the triterpene saponins in the plant and also the separation of four alkaloids, and remarkable qualitative and quantitative variations were revealed.
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