Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum.

@article{Grady2001NicotinicAS,
  title={Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum.},
  author={Sharon R. Grady and Natalie M. Meinerz and Jian Cao and A Martyn Reynolds and Marina R. Picciotto and Jean Pierre Changeux and John McIntosh and Michael J. Marks and Allan C. Collins},
  journal={Journal of neurochemistry},
  year={2001},
  volume={76 1},
  pages={258-68}
}
Acetylcholine release stimulated by nicotinic agonists was measured as radioactivity released from perfused synaptosomes prepared from mouse interpeduncular nucleus (IPN) that had been loaded with [(3)H]choline. Agonist-stimulated release was dependent upon external calcium and over 90% of released radioactivity was acetylcholine. The release process was characterized by dose response curves for 13 agonists and inhibition curves for six antagonists. alpha-Conotoxin MII did not inhibit this… CONTINUE READING

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