Nicotinic acetylcholine receptors in mouse and rat optic nerves.

  title={Nicotinic acetylcholine receptors in mouse and rat optic nerves.},
  author={Chang-E. Zhang and Yakov I. Verbny and Sameh A Malek and Peter K. Stys and Shing Yan Chiu},
  journal={Journal of neurophysiology},
  volume={91 2},
Receptor-mediated calcium signaling in axons of mouse and rat optic nerves was examined by selectively staining the axonal population with a calcium indicator. Nicotine (1-50 microM) induced an axonal calcium elevation that was eliminated when calcium was removed from the bath, suggesting that nicotine induces calcium influx into axons. The nicotine response was blocked by d-tubocurarine and mecamylamine but not alpha-bungarotoxin, indicating the presence of calcium permeable, non-alpha7… CONTINUE READING


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