Nicotinic acetylcholine receptors containing alpha7 subunits are required for reliable synaptic transmission in situ.

Abstract

Nicotinic acetylcholine receptors containing alpha7 subunits are widely expressed in the nervous system. The receptors are cation-selective, relatively permeable to calcium, and avid binders of alpha-bungarotoxin. Although the receptors can act both pre- and postsynaptically, their physiological significance is unclear. Using whole-cell patch-clamp analysis… (More)

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