Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience.

@article{Moretti2004NicotinicAR,
  title={Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience.},
  author={Milena Moretti and Silvia Vailati and Michele Zoli and Giordano Lippi and Loredana Riganti and Renato Longhi and Alessandro Viegi and Francesco Clementi and Cecilia Gotti},
  journal={Molecular pharmacology},
  year={2004},
  volume={66 1},
  pages={85-96}
}
By acting through retinal nicotinic acetylcholine receptors (nAChRs), acetylcholine plays an important role in the development of both the retina and central visual pathways. Ligand binding and immunoprecipitation studies with subunit-specific antibodies showed that the expression of alphaBungarotoxin (alphaBgtx) and high-affinity epibatidine (Epi) receptors is regulated developmentally and increases until postnatal day 21 (P21). The increase in Epi receptors is caused by a selective increase… CONTINUE READING