Nicotinic acetylcholine receptor antagonistic property of the selective dopamine uptake inhibitor, GBR-12909 in rat hippocampal slices.

@article{Szsz2007NicotinicAR,
  title={Nicotinic acetylcholine receptor antagonistic property of the selective dopamine uptake inhibitor, GBR-12909 in rat hippocampal slices.},
  author={Bernadett K Sz{\'a}sz and E. Sylvester Vizi and J{\'a}nos P{\'e}ter Kiss},
  journal={Neuroscience},
  year={2007},
  volume={145 1},
  pages={344-9}
}
Previously we found that inhibitors of noradrenaline (NA) and/or 5-HT reuptake are able to inhibit neuronal nicotinic acetylcholine receptors (nAChRs) in the CNS most probably by a channel blocker-type mechanism. The aim of our study was to clarify whether selective dopamine uptake inhibitors also possess this property, therefore we investigated the effect of GBR-12909 on the nicotine-evoked release of [3H]NA from rat hippocampal slices. GBR-12909, similar to selective NA and 5-HT uptake… CONTINUE READING