Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity

@inproceedings{GalleTreger2016NicotinicAR,
  title={Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity},
  author={Lauriane Galle-Treger and Yuzo Suzuki and Nisheel Patel and Ishwarya Sankaranarayanan and Jennifer L. Aron and Hadi Maazi and Lin Chen and Omid Akbari},
  booktitle={Nature communications},
  year={2016}
}
Allergic asthma is a complex and chronic inflammatory disorder that is associated with airway hyperreactivity (AHR) and driven by Th2 cytokine secretion. Type 2 innate lymphoid cells (ILC2s) produce large amounts of Th2 cytokines and contribute to the development of AHR. Here, we show that ILC2s express the α7-nicotinic acetylcholine receptor (α7nAChR), which is thought to have an anti-inflammatory role in several inflammatory diseases. We show that engagement of a specific agonist with α7nAChR… CONTINUE READING
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