Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy

@article{Zhang2011NicotinicAR,
  title={Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy},
  author={Guoqiang Zhang and Alison P. Thomas and Amanda L Marshall and Kelly A Kernan and Yanyuan Su and Yi cheng Zheng and Jiro Takano and Takaomi C Saido and Allison A. Eddy},
  journal={Laboratory Investigation},
  year={2011},
  volume={91},
  pages={106-123}
}
The nicotinic acetylcholine receptor α1 (nAChRα1) was investigated as a potential proinflammatory molecule in the kidney, given a recent report that it is an alternative urokinase plasminogen activator (uPA) receptor, in addition to the classical receptor uPAR. Two animal models and in vitro monocyte studies were involved: (1) In an ApoE−/− mouse model of… CONTINUE READING