Nicotinic Acid-Induced Flushing Is Mediated by Activation of Epidermal Langerhans Cells

@article{Beny2006NicotinicAF,
  title={Nicotinic Acid-Induced Flushing Is Mediated by Activation of Epidermal Langerhans Cells},
  author={Zolt{\'a}n Beny{\'o} and Andreas Gille and Clare L. Bennett and Bj{\"o}rn E Clausen and Stefan Offermanns},
  journal={Molecular Pharmacology},
  year={2006},
  volume={70},
  pages={1844 - 1849}
}
  • Zoltán Benyó, Andreas Gille, +2 authors Stefan Offermanns
  • Published 2006
  • Biology, Medicine
  • Molecular Pharmacology
  • The antidyslipidemic drug nicotinic acid (niacin) has been used for decades. One of the major problems of the therapeutical use of nicotinic acid is a strong cutaneous vasodilation called flushing, which develops in almost every patient taking nicotinic acid. Nicotinic acid-induced flushing has been shown to be mediated by the nicotinic acid receptor GPR109A and to involve the formation of vasodilatory prostanoids. However, the cellular mechanisms underlying this short-term effect are unknown… CONTINUE READING

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