Nicotinic Acetylcholine Receptor Agonists Attenuate Septic Acute Kidney Injury in Mice by Suppressing Inflammation and Proteasome Activity

@inproceedings{Chatterjee2012NicotinicAR,
  title={Nicotinic Acetylcholine Receptor Agonists Attenuate Septic Acute Kidney Injury in Mice by Suppressing Inflammation and Proteasome Activity},
  author={Prodyot K. Chatterjee and Michael M Yeboah and Oonagh Dowling and Xiangying Xue and Saul R. Powell and Yousef Al-Abed and Christine N Metz},
  booktitle={PloS one},
  year={2012}
}
Sepsis is one of the leading causes of acute kidney injury (AKI). Septic patients who develop acute kidney injury (AKI) are at increased risk of death. To date there is no effective treatment for AKI or septic AKI. Based on their anti-inflammatory properties, we examined the effects of nicotinic acetylcholine receptor agonists on renal damage using a mouse model of lipopolysaccharide (LPS)-induced AKI where localized LPS promotes inflammation-mediated kidney damage. Administration of nicotine… CONTINUE READING
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