Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine

  title={Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine},
  author={Zuojun Ren and Shobha Mummalaneni and Jie Qian and Clive Marc Baumgarten and John A. Desimone and Vijay Lyall},
  journal={PLoS ONE},
Nicotine elicits bitter taste by activating TRPM5-dependent and TRPM5-independent but neuronal nAChR-dependent pathways. The nAChRs represent common targets at which acetylcholine, nicotine and ethanol functionally interact in the central nervous system. Here, we investigated if the nAChRs also represent a common pathway through which the bitter taste of nicotine, ethanol and acetylcholine is transduced. To this end, chorda tympani (CT) taste nerve responses were monitored in rats, wild-type… 

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  • Zuojun Ren, M. Rhyu, V. Lyall
  • Biology, Psychology
    American journal of physiology. Gastrointestinal and liver physiology
  • 2013
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