Nicotinic α5 subunits drive developmental changes in the activation and morphology of prefrontal cortex layer VI neurons.

@article{Bailey2012NicotinicS,
  title={Nicotinic α5 subunits drive developmental changes in the activation and morphology of prefrontal cortex layer VI neurons.},
  author={Craig D C Bailey and Nyresa C. Alves and Raad Nashmi and Mariella de Biasi and Evelyn K Lambe},
  journal={Biological psychiatry},
  year={2012},
  volume={71 2},
  pages={120-8}
}
BACKGROUND Nicotinic signaling in prefrontal layer VI pyramidal neurons is important to the function of mature attention systems. The normal incorporation of α5 subunits into α4β2* nicotinic acetylcholine receptors augments nicotinic signaling in these neurons and is required for normal attention performance in adult mice. However, the role of α5 subunits in the development of the prefrontal cortex is not known. METHODS We sought to answer this question by examining nicotinic currents and… CONTINUE READING
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