Nicotine withdrawal increases stress-associated genes in the nucleus accumbens of female rats in a hormone-dependent manner.

@article{Torres2015NicotineWI,
  title={Nicotine withdrawal increases stress-associated genes in the nucleus accumbens of female rats in a hormone-dependent manner.},
  author={O Torres and J. Pipkin and Patrick M Ferree and L. M. Carcoba and L. E. O'Dell},
  journal={Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco},
  year={2015},
  volume={17 4},
  pages={
          422-30
        }
}
  • O Torres, J. Pipkin, +2 authors L. E. O'Dell
  • Published in
    Nicotine & tobacco research…
    2015
  • Medicine
  • INTRODUCTION Previous work led to our hypothesis that sex differences produced by nicotine withdrawal are modulated by stress and dopamine systems in the nucleus accumbens (NAcc). We investigated our hypothesis by studying intact females to determine whether the mechanisms that promote withdrawal are ovarian-hormone mediated. METHODS Female rats were ovariectomized (OVX) or received sham surgery (intact) on postnatal day (PND 45-46). On PND 60, they received sham surgery (controls) or were… CONTINUE READING

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