Nicotine use in schizophrenia: The self medication hypotheses

@article{Kumari2005NicotineUI,
  title={Nicotine use in schizophrenia: The self medication hypotheses},
  author={Veena Kumari and Peggy Postma},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2005},
  volume={29},
  pages={1021-1034}
}
  • V. Kumari, P. Postma
  • Published 2005
  • Psychology, Medicine
  • Neuroscience & Biobehavioral Reviews
The behavioural and cognitive effects of nicotine in schizophrenia have received much interest in recent years. The rate of smoking in patients with schizophrenia is estimated to be two- to four-fold the rate seen in the general population. Furthermore such patients favour stronger cigarettes and may also extract more nicotine from their cigarettes than other smokers. The question has been raised whether the widespread smoking behaviour seen in this patient group is in fact a manifestation of a… Expand
THE RELATIONSHIP BETWEEN SMOKING AND SCHIZOPHRENIA
Smoking is the most common disorder in a population with severe mental illness. Smoking frequency of individuals with schizophrenia is 2-4 times higher than the general population. Smoking alsoExpand
Smoking in schizophrenic patients: A critique of the self-medication hypothesis.
TLDR
Closer examination of the literature points to the possibility that smoking is less beneficial on schizophrenic symptomology than generally assumed while clearly increasing the risk of cancer and other smoking-related diseases responsible for early mortality. Expand
Cognitive performance and smoking in first-episode psychosis: the self-medication hypothesis
TLDR
The results suggest that smoking may constitute a marker of a more severe illness and improve attention and working memory to a similarly modest extent as atypical antipsychotics and could reflect an effort to ameliorate these cognitive dysfunctions previous to treatment instauration. Expand
Self-reported motivation to smoke in schizophrenia is related to antipsychotic drug treatment
TLDR
Schizophrenia patients reported a stronger motivation to smoke than controls for reasons related to pleasure from the act of smoking, as well as a need for psychomotor stimulation, which may be related to anticholinergic load of psychiatric medications. Expand
Tobacco smoking and schizophrenia: re-examining the evidence
TLDR
This article explores three current hypotheses that explain the higher prevalence of smoking in people diagnosed with schizophrenia and identifies certain genes that confer vulnerability for both schizophrenia and nicotine dependence. Expand
Smoking in schizophrenia: cognitive impact of nicotine and relationship to smoking motivators
TLDR
This is the first study to show that neurocognitive effects of smoking may influence self-reported smoking motivation, and preliminary findings indicate that evidence for such effects is apparent even in small samples — particularly for VSWM. Expand
Tobacco smoking in schizophrenia: investigating the role of incentive salience
TLDR
The hypothesis that the development of delusions and the incentive motivational aspects of smoking may share a common biological substrate is supported, which may offer some explanation for the elevated rates of smoking and other drug use in people with psychotic illness. Expand
Effects of Nicotine on Schizophrenia and Antipsychotic Medications: A Systematic Review
TLDR
Prior to smoking cessation implementation, it is crucial to understand on the ways and reasons for schizophrenia patients to consume nicotine for self-medicate symptoms which may lead to the development of new treatments for schizophrenia and nicotine dependence. Expand
The relationship between nicotine and psychosis
TLDR
A bidirectional relationship has been proposed wherein cigarette smoking may be causally related to risk of psychosis, possibly via a shared genetic liability to smoking and psychosis. Expand
Medications Development for the Treatment of Nicotine Dependence in Individuals with Schizophrenia
TLDR
The purpose of this article is to review the results of the studies conducted to date and propose some potential pharmacotherapies based on the current knowledge of the pathophysiology of both smoking and schizophrenia. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 210 REFERENCES
Tobacco use in schizophrenia: a study of cotinine concentrations in the saliva of patients and controls
TLDR
The correlation between high cotinine levels and negative symptomatology may reflect an attempt by schizophrenic patients to overcome the emotional withdrawal and thus the results may lend support to a self-medication hypothesis. Expand
Schizophrenic patients who smoke have a faster finger tapping rate than non-smokers
TLDR
Smoking status and finger tapping rate, a measure of central processing, in schizophrenia patients treated with atypical antipsychotics was examined and smokers showed significantly faster finger tapping rates than non-smokers. Expand
Cigarette smoking: implications for psychiatric illness.
  • A. Glassman
  • Psychology, Medicine
  • The American journal of psychiatry
  • 1993
TLDR
It is the view of this author that both cigarette smoking and smoking cessation are highly relevant to the clinical psychiatrist in the care of patients and that they are potentially a source of important insights into psychopathology. Expand
Clozapine decreases smoking in patients with chronic schizophrenia
TLDR
The changes that occurred in smoking among a group of treatment-refractory patients with schizophrenia when they were switched from haloperidol to clozapine in an ongoing double-blind trial examining treatment response at three distinct clozAPine plasma level ranges are reported. Expand
Nicotine Withdrawal and Psychiatric Symptoms in Cigarette Smokers with Schizophrenia
TLDR
Acute exacerbation of psychiatric symptoms is an unlikely explanation for any difficulty smokers with schizophrenia have in early abstinence, and completers did not endorse increased nicotine withdrawal symptoms. Expand
Increased levels of the nicotine metabolite cotinine in schizophrenic smokers compared to other smokers
TLDR
Schizophrenic patients' higher dose of nicotine may target different receptors than those activated by the lower doses self-administered by most nonschizophrenic smokers, and high doses may activate low-affinity alpha-7 nicotinic receptors, associated with deficits in sensory inhibition in schizophrenia. Expand
Schizophrenia and nicotine use: report of a pilot smoking cessation program and review of neurobiological and clinical issues.
TLDR
An evaluation of a smoking cessation program for 24 smokers with schizophrenia shows that 50 percent completed the program, 40 percent decreased use by 50 percent, and 13 percent remained abstinent for 6 months. Expand
Nicotine dependence in schizophrenia: clinical phenomena and laboratory findings.
TLDR
Clinical data suggest that smoking in schizophrenia may represent an attempt to self-medicate symptoms of the illness, and preclinical findings support a potential role of nicotine in medicating negative symptoms in particular. Expand
Smoking, smoking withdrawal and schizophrenia: case reports and a review of the literature
TLDR
An overview of evidence linking cigarette smoking and schizophrenia is presented, and three cases suggesting that nicotine withdrawal leads to an exacerbation of schizophrenic symptoms are described. Expand
Nicotine–Haloperidol Interactions and Cognitive Performance in Schizophrenics
TLDR
The effects of nicotine are demonstrated in reversing some of the adverse side effects of haloperidol and improving cognitive performance in schizophrenia. Expand
...
1
2
3
4
5
...