Nicotine suppresses apoptosis by regulating α7nAChR/Prx1 axis in oral precancerous lesions

@inproceedings{Wang2017NicotineSA,
  title={Nicotine suppresses apoptosis by regulating α7nAChR/Prx1 axis in oral precancerous lesions},
  author={Chunxiao Wang and Wenwen Niu and Hui Chen and Ni Shi and Dian He and Min Zhang and Lihua Ge and Zhenchuan Tian and Moci Qi and Tong Chen and Xiaofei Tang},
  booktitle={Oncotarget},
  year={2017}
}
Nicotine, a tumor promoter in tobacco, can increase Peroxiredoxin (Prx1) and nicotinic acetylcholine receptors (nAChRs) in oral squamous cell carcinoma (OSCC). In the present study, we investigate the effects of nicotine in oral precancerous lesions focusing on apoptosis and nAChR/Prx1 signaling. We detected expression of Prx1, α3nAChR, α7nAChR, phosphorylation of mitogen-activated protein kinases (MAPK) and apoptosis in dysplastic oral keratinocyte (DOK) cells as well as in 4-nitroquinoline 1… CONTINUE READING