Nicotine stimulation of dorsal raphe neurons: effects on laterodorsal and pedunculopontine neurons.

@article{Mihailescu2001NicotineSO,
  title={Nicotine stimulation of dorsal raphe neurons: effects on laterodorsal and pedunculopontine neurons.},
  author={Stefan Mihailescu and Rub{\'e}n Guzm{\'a}n-Mar{\'i}n and Ren{\'e} Drucker-Col{\'i}n},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2001},
  volume={11 5},
  pages={359-66}
}
Previous studies showed that nicotine suppresses the ponto-geniculo-occipital (PGO) spikes of rapid eye movement (REM) sleep in cats. This effect may depend on stimulation of dorsal raphe nucleus (DRN) serotoninergic neurons that inhibit the pedunculopontine (PPT) and laterodorsal tegmental (LDT) cholinergic neurons, generators of PGO spikes. For testing this hypothesis 37 experiments were performed in rat midbrain slices. Nicotine (2 mM), administered locally into DRN, significantly increased… CONTINUE READING
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