Nicotine serves as a feature-positive modulator of Pavlovian appetitive conditioning in rats.

@article{Palmatier2004NicotineSA,
  title={Nicotine serves as a feature-positive modulator of Pavlovian appetitive conditioning in rats.},
  author={Matthew I. Palmatier and Jessica L. Peterson and Jamie L. Wilkinson and Rick A Bevins},
  journal={Behavioural pharmacology},
  year={2004},
  volume={15 3},
  pages={183-94}
}
The present experiments examined whether a nicotine state could set the occasion for a pairing between visual cues and a rewarding outcome in rats. Following nicotine administration, presentation of a conditional stimulus (CS; light-on) was followed by brief access to a sucrose solution. When saline was administered, the same CS was presented but was not followed by any consequence. In Experiment 1, two groups assessed whether rats could acquire this Pavlovian feature-positive discrimination… CONTINUE READING