Nicotine self-administration in rats: estrous cycle effects, sex differences and nicotinic receptor binding

@article{Donny2000NicotineSI,
  title={Nicotine self-administration in rats: estrous cycle effects, sex differences and nicotinic receptor binding},
  author={Eric C. Donny and Anthony R. Caggiula and Peter P. Rowell and Maysa A. Gharib and V. Maldovan and Sheri Booth and M. M. Mielke and Alycia Hoffman and Sarah E. McCallum},
  journal={Psychopharmacology},
  year={2000},
  volume={151},
  pages={392-405}
}
Rationale: Research on smoking behavior and responsiveness to nicotine suggests that nicotine's effects may depend on the sex of the organism. Objective: The present study addressed four questions: 1) Will female rats self-administer nicotine? 2) Does self-administration by females vary as a function of estrous cycle? 3) Does self-administration by females differ from that of males? 4) Does self-administration of nicotine result in up-regulation of nicotinic receptor binding and are these… CONTINUE READING
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