Nicotine self-administration and withdrawal: modulation of anxiety in the social interaction test in rats

@article{Irvine2001NicotineSA,
  title={Nicotine self-administration and withdrawal: modulation of anxiety in the social interaction test in rats},
  author={Elaine E Irvine and M. Bagnalasta and Cristina Marcon and Caterina Motta and Michela A. Tessari and Sandra E. File and Christian Chiamulera},
  journal={Psychopharmacology},
  year={2001},
  volume={153},
  pages={315-320}
}
Rationale: Most smokers report smoking has an anxiolytic effect, which may contribute to nicotine dependence. Objective: To examine effects in the social interaction test (SI) of anxiety after 4 weeks' self-administered nicotine (15 infusions of 0.03 mg/kg, totalling 0.45 mg/kg per day), and after 24 and 72 h of withdrawal. The effect of exposure to the operant chamber on withdrawal responses was also examined. Methods: Animals were trained to self-administer saline or nicotine and after 4… CONTINUE READING

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